Welcometo the Jiang research group at Cornell University
Open PositionsGraduate Research Assistants in biomedical engineering, immunology, organic chemistry, genetic medicine and cell/cancer biology
Highlights
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An important challenge in many biomedical and engineering applications is the prevention of unwanted nonspecific biomolecular and microorganism attachment on surfaces. Since the early 2000s, we have proposed the concept of super-hydrophilic zwitterionic materials, provided a molecular-level understanding of non-fouling mechanisms and developed several new classes of zwitterionic materials, including poly(carboxybetaine), poly(sulfobetaine), poly(trimethylamine N-oxide), poly(zwitterionic phosphatidylserine), and glutamic acid (E) and lysine (K)-containing poly(peptides). We have demonstrated no capsule formation upon subcutaneous implantation in mice up to one year, expansion of hematopoietic stem and progenitor cells (HSPCs) without differentiation, no anti-coagulants needed for artificial lungs in sheep, no antibodies generated against zwitterionic polymers and long-lasting environmentally benign marine coatings. These highly biocompatible zwitterionic materials are excellent alternatives to widely used poly(ethylene glycol) (PEG) counterparts. At Cornell, we aim to (a) integrate immunology into our biomaterial and drug delivery research programs and (b) translate our biomaterials and drug delivery technologies into medical and engineering practice. More specifically, we focus on two areas.

Drug delivery and cancer immunotherapy: We are developing low-immunogenicity and targeted viral and non-viral carriers (e.g., lipid nanoparticles, extracellular vehicles, AAVs, protein conjugates and fusion proteins) for the delivery of mRNAs, DNAs, proteins and small molecules. In collaborations with Weill Cornell Medicine, Cornell Vet School and others, we are working on cancer and infectious disease prevent and treatment vaccines along treatments for several diseases.
Biomaterials and regenerative/precious medicine: We are developing highly biocompatible materials, which are biologically inert, immunosuppressive or active, using both rational design and combinatorial screening. In collaborations with Weill Cornell Medicine and others, we are working on controlled cultures of iPSCs and organoids in vitro along with capsule-free long-term implants and anticoagulant-free blood-contacting devices in vivo.
We take a unique holistic approach to our research at the interfaces of materials and biological sciences from fundamental principles to applications. Novel materials and drug carriers are designed, synthesized, tested, improved and applied for a wide range of applications all within our group. The nature of our highly interdisciplinary and collaborative research program enables us to strive towards understanding nature at all levels and to solve real-world challenging problems. Creative ideas and innovative technologies with high and broad impacts are always our emphasis.
Please click on the icons above or browse our "research" section to learn more about our lab's work.
Group News
Oct 2021 - Ruoxin Li, the first-year BME student, joined the group. She is co-advised by Prof. Matthew DeLisa, Chemical Engineering.
May 2021 - Cornell Alumni Magazine about our work on May/June Edition (Read more)
May 2021 - Cornell twitter about our work on May 4 (Read more)
May 2021 - Wenting Gao, the first-year BBS student, joined the group. She is co-advised by Prof. Deborah Fowell, immunology.
May 2021 - Sean Bailey, the second-year MSE student, joined the group.
April 2021 - A virtual field trip of the Jiang Lab for 3rd-4th graders by Erica Wagner (Read more)
March 2021 - Congratulations to Erica Wagner for winning a 2021 National Science Foundation (NSF) Graduate Research Fellowship (GRFP). (Read more)
March 2021 - Dr. Xiaoran Hu joined the lab as a postdoctoral fellow.
March 2021 - Dr. Di Liu joined the lab as a postdoctoral fellow.
March 2021 - Cornell Research feature on our work (Read more)
Febrary 2021 - Dr. Liang Fang joined the lab as a postdoctoral fellow.
December 2020 - Patrick McMullen received his Ph.D degree in Chemical Engineering from University of Washington and joined the lab as a postdoctoral fellow.
October 2020 - Amy Laflin, the first-year BME Ph.D. student, joined the lab.
October 2020 - Erica Wagner, the first-year BME Ph.D. student, joined the lab.
September 2020 - Dr. Wenchao Gu joined the lab as a research associate.
September 2020 - Dr. Nisha Kannan joined the lab as a postdoctoral fellow.
July 2020 - Dr. Shaoyi Jiang joined the Cornell Center for Immunology.
June 2020 - Dr. Zhefang Yuan (Research associate), Sijin Luzhong (BME graduate student), Chenjue Tang (BME graduate student), Patrick McMullen (visiting student) and Xiaohui Li (visiting scholar) moved from the University of Washington and joined BME at Cornell.
June 2020 - Dr. Shaoyi Jiang joined the Meinig School of Biomedical Engineering at Cornell as the Robert S. Langer ’70 Family and Friends Professor in June 2020

April 2022
Quick Info
Locations
Contact
Weill Hall 135
Jiang Office
(607)-255-2152
Weill Hall 131, 139
Student office
Cornell University, Ithaca campus
Weill Hall 132, 134, 138 and 140
Laboratory space
Cornell University, Ithaca campus
Locations

Contact
Weill Hall 135
Jiang Office
(607)-255-2152
Weill Hall 131, 139
Student office
Cornell University, Ithaca campus
Weill Hall 132, 134, 138 and 140
Laboratory space
Cornell University, Ithaca campus